目的　报告多孔磷酸三钙 ( tricalcium phosphate，TCP ) 治疗 38 例腔隙性骨缺损患者至少随访 2 年的临床效果。方法　2008 年 3 月至 2011 年 9 月，对 38 例腔隙性骨缺损患者采用多孔磷酸三钙填充修复，男 22 例，女 16 例。年龄 3～58 岁，平均 23 岁。缺损范围最小 0.72 cm3，最大 151.88 cm3，平均 济南军区总医院骨病科许宋锋
35.62 cm3。随访 25～65 个月，平均 41 个月。采用在体 TCP 人工骨降解的 X 线片并图像分析软件分析植骨区灰度变化，计算材料降解率，动态观察多孔磷酸三钙人工骨降解情况。结果　所有患者术后未见任何过敏或毒性反应。随时间延长，人工骨材料逐渐降解，新骨逐渐形成，以术后 1 年内降解速度最快。患者年龄越小 ( ＜16 岁 )、肿瘤体积越小 ( ＜10 cm3 )，新骨成骨、材料降解速度越快。结论　多孔磷酸三钙人工骨可以用作良性或侵袭性骨肿瘤骨缺损的修复，平均随访 41 个月，疗效满意。

Objective  To assess the over-2-year clinical outcomes of porous tricalcium phosphate ( TCP ) for the repair of lacunar bone defects. Methods  A total of 38 patients with lacunar bone defects underwent the repair with porous TCP from March 2008 to September 2011, including 22 males and 16 females, whose average age was 23 years old ( range; 3-58 years ). Tumor sizes varied from 0.72 cm3 to 151.88 cm3, with the average size of 35.62 cm3. All patients were followed up for a mean period of 41 months ( range; 25-65 months ). The in vivo biodegradation rate of the implanted TCP was evaluated based on the radiographic analyzing method. The gray scale change of the grafting area in plain X-ray images was used to assess the degradation of porous TCP. Results There was neither significant reverse reaction to the transplanted material nor locally inflammatory reaction in all of the cases. Bone defects were repaired gradually, in company with the degradation of TCP materials and the formation of new bone. The rates of TCP degradation and new bone formation were fastest in the first year postoperatively. The younger the patients were ( <16 years old ) and the smaller the tumor size was ( <10 cm3 ), the faster the rates were.Conclusions  The porous TCP is an ideal material for the repair of lacunar bone defects caused by benign or invasive tumors, and the over-2-year follow-up results are satisfactory .