万小云,女,主任医师,
妇科肿瘤科主任兼
肿瘤一科主任,博士,博士生导师。1962年10月出生,1985年8月毕业于浙江医科大学医疗系,1995年8月获医学硕士学位,1997年公派赴日本国岐阜大学医学部学习,期间对
妇科恶性
肿瘤的发生、发展以及治疗等方面进行了深入而系统的研究,于2002年3月获医学博士学位后返回浙大妇产科医院。一直从事妇产科临床、科研及教学工作,主要方向为
妇科肿瘤临床与基础研究;承担科研课题多项。近年在国内外各类期刊发表论著40余篇,其中SCI源期刊论文10余篇,先后共培养硕士10名。
主要学术兼职
1.浙江省抗癌协会
妇科肿瘤分会,副主任委员
2.浙江省医学会
肿瘤外科学分会,委员,学科专长:
妇科肿瘤
近年发表的主要论著
1. Mao Y, Wan X, Lv W et al. Relapsed or refractory gestational trophoblastic neoplasia treated with etopside, cisplatin/etopside,methotrexate and actinomycin D (EP-EMA) regimen. International Journal of Gynecology and Obstetrics 2007 July;98(1): 44-47.(通讯作者)
2. Wan X, Li J, Xie X, et al. PTEN augments doxorubicin-induced apoptosis in PTEN-null Ishikawa cells. International Journal of Gynecological Cancer 2007Jul 13; 17(4):808-812.
3. Wan X, Li J, Xie X. Extrauterine choriocarcinoma of the greater omentum after tubal pregnancy: case report. International Journal of Gynecological Cancer 2006 May;16(3):1476-1478.
4. 万小云。子宫内膜癌流行病学及预后不良高危因素。实用
肿瘤杂志 2006;21(2):108-110.
5. 万小云,毛愉燕,横山康宏。PTEN基因转染的子宫内膜癌细胞对阿霉素诱导的凋亡的敏感性。中华
肿瘤杂志 2005;27(9):15-17.
6. 万小云,石一复,李娟清。PTEN基因对子宫内膜癌细胞生长的抑制作用。中华
肿瘤杂志 2004;26(5):275-278.
7. Wan X, Yokoyama Y, Shinohara A, et al. PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway. Cell Death and Differentiation 2002; 9(4):414~420.
8. Yokoyama Y, Wan X, Takahashi Y, et al. Divalent hammerhead ribozyme targeting template region of human telomerase RNA has potent cleavage activity, but less inhibitory activity on telomerase. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2002;405(1):32-37.
9. Yokoyama Y, Wan X, Shinohara A, et al. Hammerhead ribozymes to modulate telomerase activity of endometrial carcinoma cells. Human Cell 2001; 14: 223~231.
10. Yokoyama Y, Wan X, Takahashi Y, et al. Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus. Molecular Human Reproduction 2001; 7(9): 853~857.
11. Yokoyama Y, Wan X, Shinohara A, et al. Expression of PTEN and PTEN pseudogene in endometrial carcinoma. International Journal of Molecular medicine 2000; 6(1):47~50.