刘正言，男，江苏省徐州人。主任医师，副教授，复旦大学医学博士，美国加州大学（UCSF）博士后，多次国内外进修和培训。国内外学术交流：Society for Neuroscience. 2003. New Orleans, USA.；Society for Neuroscience. 2004. San Diego, USA.；AANS. 2004. San Francisco, USA.；International Society for Cerebral Blood Flow and Metabolism. 2005. Amstadam, Netherlands.International Neurosurgery Education and Research, 2009. Florida, USA多次参加国外培训、进修、国内举办的学术活动和学术交流。专 著：参编和翻译专著10余部，如：《现代神经
外科学》、《实用
外科学》、《实用神经病学》、《现代
肿瘤学》、《
中枢神经系统
肿瘤》等 。承担科研项目：2007-2011：国家十一五科技支撑计划重大项目---脑卒中
外科综合治疗技术体系研究。1998.9－2001.12承担上海市医学发展重点课题：“去骨瓣减压术对局灶性脑缺血的保护机制及其前瞻性临床研究”。完成并通过鉴定。2003.3－2005.7在美国加州大学旧金山分校进修时主要从事脑缺血后内源性神经再生与功能重建的研究，如：炎症反应与神经再生；优越环境（EE）对脑缺血和放射治疗后神经再生的影响；EMX1基因对神经再生的影响；低血糖对神经再生的影响等多项课题。均已完成并发表多篇SCI文章。2006.1－2008.1承担华山医院科研课题“抗凋亡治疗对延长缺血诱导的内源性神经干细胞生存的研究”。目前已完成。2006.1起作为主要负责人之一承担“蒂清治疗脑胶质瘤与转移瘤前瞻、开放、对照临床研究”。目前正在研究中。发表论文及会议论文摘要：Chengyu Xia, Zhengyan Liu?, Rong Zhang, Ying Mao, Yin Wan. Primary intrinsic optic chiasm germinoma. Journal of Clinical Neuroscience 18 (2011) 860–862.(通讯作者）刘正言，潘力。颅咽管瘤的治疗。国外医学神经病学神经
外科分册，1998，25(3)： 132～135刘正言，潘力，王滨江，王恩敏，张南，杨立群。伽玛刀和立体定向32P囊内放疗联合治疗颅咽管瘤。中国临床神经科学，1998，6(2)： 86～89刘正言，周良辅。去骨瓣减压术治疗大面积脑梗死的现状和进展。中国神经精神疾病杂志，2000，26(3)： 190～191刘正言，周良辅，黄峰平，毛颖。去骨瓣减压术治疗大面积脑梗死前瞻性临床研究方案及初步临床报道。中国临床神经科学，2001，9(1)：5刘正言，周良辅，黄峰平，毛颖。去骨减压对大鼠局灶性脑缺血保护作用的有效时间窗。中国临床神经科学，2001，9(2)：162～165刘正言，周良辅，毛颖，黄峰平。去骨减压对大鼠局灶性脑缺血细胞凋亡的影响。中国临床神经科学，2003，11(1)：37～41刘正言，周良辅，任惠民，毛颖，黄峰平。去骨瓣减压术对大鼠局灶性脑缺血后脑水肿、血脑屏障、脑血流变化的影响。中国临床神经科学，2006，14(1)：72～76董建平 刘正言 罗志伟 董庆汉 董辉。经额部小切口—鼻内镜额隐窝开窗联合入路治疗开颅术后额窦脓肿。中国临床神经科学，2006，14(5)：512刘正言 周良辅 毛颖 黄峰平 丁玎。去骨瓣减压术治疗大面积脑梗死的短期疗效评价。中国临床神经科学，2007，15(1)：59～63Zhengyan Liu, Yang Fan, Seok Joon Won, Melanie Neumann, Dezhi Hu, Liangfu Zhou, Philip R. Weinstein, Jiaing Liu. Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia. Stroke, 2007,38: 146-152 （SCI, 影响因子 5.855）Yang Fan, Zhengyan Liu*, Philip R. Weinstein, John R. Fike, Jialing Liu. Environmental enrichment enhances neurogenesis and improves functional outcome after cranial irradiation. European Journal of Neuroscience, 2007, 25: 38-46 （SCI, 并列第一作者，影响因子3.949）Shwuhuey M Hong, Zhengyan Liu*, Yang Fan, Melanie Neumann, Seok Joon Won, Diana Lac, Xuanmin Lum, Philip R. Weinstein, Jialing Liu. Reduced hippocampal neurogenesis and skill reaching performance in adult Emx1 mutant mice. Experimental Neurology, 2007, 206(1):24-32. （SCI, 并列第一作者，影响因子 3.767）Jacob Raber, Yang Fan, Yasuhiko Matsumori, Zhengyan Liu, Philip R. Weinstein, John R. Fike, Jialing Liu. Irradiation attenuates neurogenesis and exacerbates ischemia-induced deficits. Ann Neurol, 2004, 55(3): 381-389 （SCI, 影响因子 7.571）Suh SW, Fan Y, Hong SM, Liu Z, Matsumori Y, Weinstein PR, Swanson RA, Liu J. Hypoglycemia induces transient neurogenesis and subsequent progenitor cell loss in the rat hippocampus. Diabetes, 2005, 54(2):500-9 （SCI, 影响因子 8.028）Z. Liu, Y. Fan, Y. Matsumori, P.R. Weinstein, J. Liu . Cerebral global ischemia induces neurogenesis but does not increase the total granule cell population in the dentate gyrus of adult gerbils. Society for Neuroscience. 2003.Z. Liu, Y. Fan, Y. Matsumori, S. Hong, PR. Weinstein, J. Liu. Enriched environment enhances progenitor cell proliferation and survival of newborn cells in the dentate gyrus following transient cerebral global ischemia. Society for Neuroscience. 2004.Z. Liu, Y. Fan, Y. S. Hong, PR. Weinstein, L. Zhou, J. Liu. Minocycline restores neurogenesis and improves functional recovery after stroke injury: different efficacy of early and delayed administration. International Society for Cerebral Blood Flow and Metabolism. 2005.Y. Fan, Z. Liu, Y. Matsumori, P.R. Weinstein, J.R. Fike, J. Liu. Low Does of Irradiation Reduces Neurogenesis but not total granule Cell Population in the Dentate Gyrus of Adult Gerbils. Society for Neuroscience. 2003 Abstract.J. Liu, Y. Fan, Z Liu, T. Kayama, P.R. Weinstein, C. Hsu, Y. Matsumori. Temporal dynamic changes in neurogenesis and newborn cell survival in the dentate gyrus ipsilateral and contralateral to focal ischemic lesion. Society for Neuroscience. 2003 Abstract.Y. Matsumori, Y. Fan, Z. Liu, T. Kayama, A. Sheldon, Z. Vexler, D.M. Ferriero, P.R. Weinstein, J. Liu. HSP70 over-expression protects the neonatal brains from hypoxic/ischemic injury. Society for Neuroscience. 2003 Abstract.Y. Fan, Z. Liu, Y. Matsumori, S. Hong, P.R. Weinstein, J.R. Fike, J. Liu. Environmental enrichment restores the neurogenesis and enhances the survival of newborn cells in the hippocampus of irradiated adult gerbils. Society for Neuroscience. 2004 Abstract.S. Hong, Y. Matsumori, Y. Fan, Z. Liu, T. Kayama, P.R. Weinstein, C. Hsu, J. Liu. Enriched environment and physical activity enhance the survival of newborn cells in the hippocampus after cerebral focal ischemia in rats. Society for Neuroscience. 2004 Abstract.Y. Matsumori, S. Hong, K. Aoyama, Y. Fan, Z. Liu, T. Kayama, A.R. Sheldon, Z.S. Vexler, D.M. Ferriero, P.R. Weinstein, J. Liu. Increased binding of HSP70 to AIF is associated with neuroprotection against neonatal hypoxic/ischemic injury in mice with HSP70 over-expression. Society for Neuroscience. 2004 Abstract.
