阳晓,女,主任医师,教授,肾
内科主任,博士研究生导师,博士研究生,毕业于1998年6月。
医疗专长
肾脏病的
诊断和治疗。擅长用中西医结合方法诊治肾脏疾病,如原发性肾病综合征、隐匿性肾小球肾炎、慢性肾炎、狼疮肾炎、糖尿病肾病、尿路感染、慢性肾衰竭等。
研究方向:
主要研究方向为腹膜透析以及慢性肾脏病中西医结合防治。承担各级科研课题15项,其中国家自然科学基金5项,美国百特基金会项目(EGP)1项。在Nephrol Dial Transplant , Lupus、中华肾脏病杂志、中国中西医结合杂志等国内外重要学术刊物发表论文100余篇,SCI收录29篇。
主要教育和工作经历:
1981、1990及1998年在湖南
中医学院先后完成大学、硕士及博士研究生学习;1998.9-2000.10.在中山大学附属第一医院肾
内科完成博士后培训(临床医学
内科肾脏病专业,合作导师叶任高教授);2003.10-2004.8以访问学者身份在希腊Al.Fleming生物医学科学研究中心免疫研究所从事分子生物学研究(导师Kollias G教授);2006.5.-2006.11.以临床观察员身份在加拿大多伦多大学Toronto General Hospital肾
内科从事腹膜透析临床研究(导师Oreopoulos D教授)。
社会兼职:
现任中国中西医结合学会理事,中国中西医结合科研院所工作委员会副主任委员,广东省中西医结合学会常务理事,广东省医师协会肾脏病分会常委;广东省中西医结合学会肾脏病专业委员会副主任委员;《中华肾脏病杂志》、《中国血液净化》等杂志编委。
论著:
1. Zeng Y, Yang X , Wang J , Fan J , Kong Q , Yu X, et al. 2012 Aristolochic Acid I Induced Autophagy Extenuates Cell Apoptosis via ERK 1/2 Pathway in Renal Tubular Epithelial Cells. PLoS ONE 2012; 7(1): e30312.(通讯作者)
2. Zeng Y, Zhang R, Wu J, Liu M, Peng W, Yu X, Yang X*. Organic anion transporter 1 (OAT1) involved in renal cell transport of aristolochic acid I. Hum Exp Toxicol. Hum Exp Toxicol. 2012 ;31(8):759-70. (通讯作者)
3. Mei Liu, Xiao Yang, Jinjin Fan, Rui Zhang, Jun Wu,Youjia Zeng, Jing Nie , Xueqing Yu. Altered tight junctions and fence function in RK-52E cells induced by aristolochic acid. Human Exp Toxicol 2012 ;31(1): 32-41,(通讯作者)
4. Yang X, Mao HP, Guo QY, Yu XQ*. Successfully managing a rapidly growing peritoneal dialysis program in Southern China. Chin Med J. 2011;124(17):2696-2700.
5. Zhu LJ, Yang X, Yu XQ:Anti-TNFα Therapies in Systemic Lupus Erythematosus. J Biomed Biotechnol. 2010;2010:465898.(通讯作者)
6. Wu J, Yang X, Zhang YF, Wang YN, Liu M, Dong XQ, Fan JJ, Yu XQ.Glucose-based peritoneal dialysis fluids downregulate toll-like receptors and trigger hyporesponsiveness to pathogen-associated molecular patterns in human peritoneal mesothelial cells.Clin Vaccine Immunol. 2010;17(5):757-63.(通讯作者)
7. Zhu LJ, Yang X, Li XY, Liu QH, Yu XQ: Suppression of tumor necrosis factor receptor associated factor (TRAF)-2 attenuates the proinflammatory and proliferative effect of aggregated IgG on rat renal mesangial cells.Cytokine2010,49(2):201-208(通讯作者)
8. Yang X, Yu X. No need for an "expiry date" in chronic peritoneal dialysis to prevent encapsulating peritoneal sclerosis: comments from around the world. Int Urol Nephrol. 2010;42(1):241-2.
9. Jun Wu , Xiao Yang, Yun-Fang Zhang , Shu-Feng Zhou, Rui Zhang , Xiu-Qing Dong , Jin-Jin Fan , Mei Liu , Xue-Qing Yu*:Angiotensin II upregulates Toll-like receptor 4 and enhances lipopolysaccharide-induced CD40 expression through nuclear factor-κB activation in rat peritoneal mesothelial cells. Inflamm Res. 2009;58(8):473-82.(共同第一作者)
10. L Zhu, X Yang, Y Ji, W Chen, W Guan, SF Zhou, and X Yu . Up-regulated renal expression of TNF-signalling adapter proteins in lupus glomerulonephritis .Lupus 2009;18 116-127(共同第一作者)
11. Yang X, Yang QQ, Guo QY, Yi CY, Mao HP, Lin JX, Jiang ZP, Yu XQ. Aeromonas salmonicida Peritonitis After Eating Fish in a Patient Undergoing CAPD. Perit Dial Int. 2008;28(3):316-7. (第一作者)
12. Zhang R, Yang X, Li J, Wu J, Peng WX, Dong XQ, Zhou SF, Yu XQ.Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury. Am J Nephrol. 2008;28(5):772-83.(共同第一作者)
13. Yang X, Fang W, Bargman JM, Oreopoulos DG. High peritoneal permeability is not associated with higher mortality or technique failure in patients on automated peritoneal dialysis. Perit Dial Int. 2008;28(1):82-92.
14. Zhu L, Yang X, Chen W, Li X, Ji Y, Mao H, Nie J, Yu X. Decreased expressions of the TNF-alpha signaling adapters in peripheral blood mononuclear cells (PBMCs) are correlated with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol. 2007;26(9):1481-9.(通讯作者)
15. Yang X, Fang W, Kothari J, Khandelwal M, Naimark D, Jassal SV, Bargman JM, Oreopoulos DG. Clinical outcomes of elderly patients undergoing chronic peritoneal dialysis: experiences from one center and a review of the literature. Int Urol Nephrol. 2007;39(4):1295-302.
16. Zhang YJ, Yang X, Kong QY, Zhang YF, Chen WY, Dong XQ, Li XY, Yu XQ.Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2).Am J Nephrol. 2006;26(4):356-62.(通讯作者)
17. Zhang YF, Yang X, Zhang YJ, Sun YL, Zou XL, Kong QY, Dong XQ, Ye XQ, Yu XQ. Peroxisome proliferator-activated receptor-gamma is expressed by rat peritoneal mesothelial cells: its potential role in peritoneal cavity local defense. Am J Nephrol. 2006;26(6):602-11. SCI Epub 2006 Dec 20.(通讯作者)
18. Yang X, Ye R, Kong Q, Yang Q, Dong X, Yu X.:CD40 is expressed on rat peritoneal mesothelial cells and upregulates ICAM-1 production.Nephrol Dial Transplant. 2004;19(6):1378-84. (通讯作者)
19. Yang X, Ye RG, Kong QY, Yang QQ, Gao Y, Zhong JH, Wang T.: CD40 Ligand expression on macrophages during peritonitis in continuous ambulatory peritoneal dialysis patients. Adv in Perit Dial 2000,16:213-215(第一作者)
20. Dimitrios G. Oreopoulos, Xiao Yang:Long-term survival on peritoneal dialysis is notadream anymore: Lessons from he East. Perit Dial Int2007.27(4): 410C412
专著:
1.腹膜透析标准操作规程。人民军医出版社。2011.参编
2.中西医结合肾脏病学。人民卫生出版社2003。第一副主编
3.中西医结合肾脏病手册。中国古籍出版社2001.9.主编
4.
中医临证指南。人民卫生出版社2001.10.第一版。参编
5.
中医诊断学高级参考书 人民卫生出版社 1998年参编
其他主要工作成绩(比如获奖情况):
作为主要完成人获得国家科技进步二等奖、中华医学科技奖二等奖等;获“广东省优秀博士后”、广东省‘千百十人才工程’先进个人、国际腹膜透析学会(ISPD)“Young Investigator Grant”和“Travel Grant”等荣誉。