徐兴顺,男,副主任医师,教授,博士,临床专长:脑血管病、重症肌无力、老年性痴呆、抑郁症及神经
内科相关疑难病症。
学习经历:
1991.9-1996.7 徐州医学院临床医学系,本科生
2003.5-2007.8 美国东田纳西州立大学医学院,博士生
2007.9-2010.2 美国艾默蕾(Emory)大学医学院,博士后
工作经历:
1996.8-2003.5 徐州医学院附属医院神经
内科,住院、主治医师,讲师
2010.3 ― 至今 苏州大学第二附属医院神经科,副主任医师,苏州大学教授、博导
学术论文&在研项目 在研项目:
1,国家自然科学基金青年基金(30700245,18万),项目名称:缺血缺氧后神经细胞发生necroptosis的机制,起止日期:2008.1-2010.12
2,国家自然科学基金面上项目(81071095, 34万),项目名称:Ahi1蛋白功能抑制引起抑郁的机制研究,起止日期:2011.1-2013.12
3,国家自然科学基金重大国际合作项目(81120108011, 260万),项目名称: Ahi1对细胞内物质转运功能的调节与抑郁,起止日期:2012.1-2016.12
4,江苏省医学重点人才计划项目,项目名称:Humanin延迟给药对脑缺血损伤后脑白质损伤和神经再生的作用,起止日期:2011.7-2016.6
以通讯作者或者第一作者发表的文章:
1. Wang C, Pei A, Chen J, Yu H, Sun ML, Liu CF, Xu X. A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice. J Neurochem, in press. (通讯作者)
2. Yu H, Zhang ZL, Chen J, Pei A, Qian X, He J, Liu CF, Xu X. Carvacrol, a food additive, provides neuroprotection on focal cerebral ischemia/reperfusion injury in mice. PLoS One. 2012 March; 7(3): e33584. (通讯作者)
3. Chen WW, Yu H, Fan HB, Zhang CC, Zhang M, Zhang C, Cheng Y, Kong J, Liu CF, Geng D, Xu X. RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons. J Neurochem. 2012 Jan;120(1):70-77. (通讯作者)
4. Chen J, Chua KW, Chua CC, Yu H, Pei A, Chua BH, Hamdy RC, Xu X, Liu CF. Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. Neurosci Lett. 2011 Jul 25;499(3):181-5. (通讯作者)
5. Xu X, Chua CC, Zhang M, Geng D, Liu CF, Hamdy RC, Chua BH. The role of PARP activation in glutamate-induced necroptosis in HT-22 cells. Brain Res. 2010 Jul 9;1343:206-12. (通讯作者)
6. Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19126-31.
7. Xu X, Chua KW, Chua CC, Liu CF, Hamdy RC, Chua BH. Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res. 2010 Oct 8;1355:189-94.
8. Xu X, Chua CC, Gao J, Chua KW, Wang H, Hamdy RC, Chua BH. Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res. 2008 Aug 28;1227:12-8.
9. Xu X, Chua CC, Kong J, Kostrzewa RM, Kumaraguru U, Hamdy RC, Chua BH. Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem. 2007 Dec;103(5):2004-14.
10. Xu X, Chua CC, Gao J, Hamdy RC, Chua BH. Humanin is a novel neuroprotective agent against stroke. Stroke. 2006 Oct;37(10):2613-9.